The tender tale of Siddhartha (the boy who becomes the beloved Buddha) accelerates toward ever more clarity in the mirror of Vajrayana and Tantric Buddhism. Multiple, modern perspectives add precision to the arc of Siddhartha’s liberating release. Through his own biological attachment, the aspiration of a neurobiology of spiritual awakening is possible. This is consistent with evolutionary theory and emerging areas in neuroscience, and finds an evocative unity with the somatic practices of Tibetan Buddhism. Referred to here as ‘Buddha’s Mom’, our human lineage provides a post-religious model of transmission, even finding compatriots in the unsung feminine energies bearing on luminaries as varied as Socrates, Jesus, Rumi, Milarepa, Dogen and Hongzhi.